Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance

Douglas Palmer,Geoff Guittard,Zulmarie Franco,Shashank Patel,Christopher A Klebanoff,Madhusudhanan Sukumar,Robert L Eil,David Clever,Lakshmi Balagopalan,Rahul Roychoudhuri, Larry Samelson,Nicholas Restifo

JOURNAL OF EXPERIMENTAL MEDICINE（2015）

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摘要

Meeting abstracts Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors within the tumor microenvironment and eliciting tumor regression. We have found that Cish, a member of the Suppressor of Cytokine Signaling (SOCS) family, is induced by TCR

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关键词

Tumor Microenvironment,Tumor Regression,Durable Regression,Proteasomal Degradation,Cancer Immunotherapy

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