How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N(2)-dG adduct of benzo[a]pyrene.

Gabriel Sholder,Amanda Creech,Edward L Loechler

DNA Repair（2015）

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摘要

•Investigating how Y-Family DNA polymerases insert dCTP with benzo[a]pyrene-N2-dG.•Four structural elements are key.•Large minor groove opening accommodates BP-moiety in BP-dG:dCTP pairing.•Small major groove opening excludes BP-moiety to prevent BP-syn-dG:dGTP pairing.•Domain contacts [Little Finger/Catalytic Core] prevent dATP/dGTP/dTTP misinsertions.

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关键词

B[a]P,+BP-dG,−BP-dG,DNAP,CC-Domain,LF-Domain,SsDpo4,SaDbh,EcDNAP IV,NCB,AS-NCB,Distal-NCB,aa

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