Influence of radiation quality on mouse chromosome 2 deletions in radiation-induced acute myeloid leukaemia.

Natalie Brown,Rosemary Finnon,Grainne Manning,Simon Bouffler,Christophe Badie

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

引用 15|浏览11

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摘要

•We have studied 2 different sets of rAMLs induced by X-rays versus neutrons.•Radiation quality does not affect the proportion of del2 or Sfpi1/PU.1 point mutation.•The chr2 MDR is refined to 5.5Mb whose position does not alter with radiation quality. We identified rAML cases with complex del2 in a subset of neutron-induced AMLs.

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关键词

Radiation,Chromosome deletion,aCGH,Sfpi1/PU.1,Myeloid leukemia,Mouse model

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