P120 Predicted indirectly recognizable HLA epitopes presented by HLA-DRB1 are related to HLA antibody formation during pregnancy
AMERICAN JOURNAL OF TRANSPLANTATION(2017)
摘要
Aim Pregnancy can prime maternal immune responses against inherited paternal HLA of the fetus, leading to the production of child-specific HLA antibodies. We previously demonstrated that donor-specific HLA antibody formation after kidney transplantation is associated with donor-derived HLA epitopes presented by recipient HLA class-II (PIRCHE-II). In the present study we evaluated the role of PIRCHE-II in the child-specific HLA antibody formation during pregnancy. Methods A total of 229 mother–child pairs were HLA-typed. For all mismatched HLA class-I molecules of the child (inherited paternal antigens (IPA), we subsequently predicted the number of HLA epitopes that can be presented by maternal HLA class-II molecules. Child-specific antigens were classified as either immunogenic HLA or non-immunogenic HLA based upon the presence of specific antibodies and correlated to PIRCHE-II numbers. Results Immunogenic HLA contained higher numbers of PIRCHE-II than non-immunogenic HLA (median increases 1.3-fold). Moreover, the probability of IPA-specific antibody production during pregnancy increased with the number of PIRCHE-II. Conclusions In conclusion, our data suggest that the number of PIRCHE-II is related to the formation of child-specific HLA antibodies during pregnancy. The present confirmation of the role of PIRCHE-II in antibody formation outside the transplantation setting suggests that the PIRCHE-II concept is a universal principle.
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关键词
translational research,science,histocompatibility,obstetrics and gynecology,pregnancy,antigen presentation,recognition
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