The Value Of In Vitro Studies In A Case Of Neonatal Diabetes With A Novel Kir6.2-W68g Mutation

Susan M O'Connell,Peter Proks,Holger Kramer,Katia K Mattis,Gregor Sachse,Caroline Joyce,Jayne A L Houghton,Sian Ellard,Andrew T Hattersley,Frances M Ashcroft,Stephen M P O'Riordan

CLINICAL CASE REPORTS（2015）

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摘要

In infants, especially with novel previously undescribed mutations of the KATP channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed.

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关键词

Glibenclamide, in vitro, K-ATP channel, neonatal diabetes

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