“Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720”

Sara M. Camp,Eddie T. Chiang,Chaode Sun,Peter V. Usatyuk,Robert Bittman,Viswanathan Natarajan,Joe G.N. Garcia,Steven M. Dudek

Chemistry and Physics of Lipids（2016）

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摘要

•Novel therapeutics are needed to treat vascular leak in ARDS.•This study characterizes effects of 4 novel FTY720 analogs on vascular permeability.•These analogs employ S1P-related signaling pathways to alter permeability.•Three novel analogs are barrier-enhancing comparable or superior to FTY720/S1P.•These mechanistic insights may assist in novel ARDS therapeutic development.

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关键词

ARDS,EC,HPAEC,MβCD,MLC,PTX,S1P,S1P1R,S1P2R,S1P3R,TER,ERK,FTY720,FITC,PBS,R)-FTY-OMe,(S)-FTY-OMe,FTY-F,FTY-G

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