Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity.

Gudrun Pahlke,C Tiessen,K Domnanich, N Kahle,Isabel Anna Maria Groh,Ilona Schreck,Carsten Weiss,Doris Marko

Toxicology Letters（2016）

引用 30|浏览17

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摘要

•CYP1A induction by alternariol is AhR-dependent.•CYP1A induction by alternariol has no substantial impact on genotoxicity.•ATX-II acts as an inducer of CYP1A expression.

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关键词

AhR,AME,AOH,ATX-II,B[a]P,cRNA,CYP1A,DCF,DCFH-DA,DMSO,EROD,MEN,ROS,siRNA,SRB,WST-1

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