mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition.

Andrew J Massey,Peter Stephens,Rebecca Rawlinson, Lauren McGurk,Ruth Plummer,Nicola J Curtin

Molecular Oncology（2016）

引用 19|浏览24

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摘要

•mTOR inhibitors induce synergistic cytotoxicity with V158411.•mTOR inhibition increases V158411 induced DNA DSBs.•Mechanism through regulation of HR and ICL repair proteins by mTOR.•DNA-PKcs overexpressing cells were more sensitive to Chk1 inhibition.•Correlation between CHEK1 and PRKDC (DNA-PKcs) mRNA levels in human tumour samples.

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关键词

Chk1,mTOR,DNA-PKcs,V158411,Double strand break repair

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