Nicotine and carbon monoxide exposure from inhalation of cigarillo smoke.

•Puffing topography, biomarkers, and physiologic effects from usual brand cigarette and Black & Mild cigarillo were tested.•Time to smoke, number of puffs, and total puff volume differed for cigarette and cigarillo smoking.•Nicotine boost after cigarettes and cigarillos was similar; cigarillo smoking caused higher CO exposure.•Exposure to nicotine and other toxicants form cigarillo use are relevant to health and regulatory considerations.