Unfolded Protein Response is Activated in Aged Retinas.

Austin R Lenox,Yogesh Bhootada,Oleg S Gorbatyuk,Roderick Fullard,Marina S Gorbatyuk

Neuroscience Letters（2015）

引用 26|浏览20

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摘要

•We demonstrated activation of the unfolded protein response in aged retinas.•We found that the NRF2 level is dramatically reduced in aged retinas.•Oxidative stress and inflammation are concomitantly activated in aging retina with ongoing UPR.

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关键词

Aging,Retina,AMD,Unfolded protein response

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