Proton channel activity of influenza A virus matrix protein 2 contributes to autophagy arrest

    Liang Li
    Liang Li
    Qian Wang
    Qian Wang
    Jiashun Li
    Jiashun Li
    Na Li
    Na Li
    Xuehua Zheng
    Xuehua Zheng

    Journal of virology, 2015.

    Cited by: 1|Bibtex|Views6|Links
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    Abstract:

    Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2)...More

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