Experience-dependent DNA methylation regulates plasticity in the developing visual cortex

Paola Tognini,Debora Napoli,Jonida Tola,Davide Silingardi,Floriana Della Ragione,Maurizio D'Esposito,Tommaso Pizzorusso

Nature neuroscience（2015）

引用 43|浏览10

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摘要

This study shows that ocular dominance plasticity (ODP) is accompanied by changes to DNA methylation at specific genes in the mouse visual cortex. The authors also show that pharmacological inhibition of the DNA methylation process can alter the functional consequence of ODP.

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关键词

Molecular neuroscience,Synaptic development,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics

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