The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

Almut Dufner,Agnes Kisser,Sandra Niendorf,Anja Basters,Sonja Reissig,Anne Schönle,Annette Aichem,Thorsten Kurz,Andreas Schlosser,Deborah Yablonski,Marcus Groettrup,Thorsten Buch,Ari Waisman,Wolfgang W Schamel,Marco Prinz,Klaus-Peter Knobeloch

Nature immunology（2015）

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摘要

Post-translational modifications regulate various signaling cascades downstream of the TCR. Knobeloch and colleagues show that the deubiquitinase USP8 is required for thymocyte development by interacting with the adaptor Gads upon TCR stimulation.

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关键词

Deubiquitylating enzymes, T cells, T-cell receptor, Signal transduction

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