A 3D human neural cell culture system for modeling Alzheimer's disease

Young Hye Kim,Se Hoon Choi,Carla D'Avanzo,Matthias Hebisch,Christopher Sliwinski,Enjana Bylykbashi,Kevin J Washicosky,Justin B Klee,Oliver Brüstle,Rudolph E Tanzi,Doo Yeon Kim

Nature protocols（2015）

引用 190|浏览16

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摘要

Human neural progenitor cells with familial Alzheimer's disease mutations are differentiated in a 3D Matrigel matrix, leading to the extracellular aggregation of amyloid-β peptides and accumulation of hyperphosphorylated and aggregated tau protein.

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关键词

Cell culture, Alzheimer's disease, Neurological models

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