The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif

Leslie K Williams,Xiaohua Zhang,Sami Caner,Christina Tysoe,Nham T Nguyen,Jacqueline Wicki,David E Williams,John Coleman,John H McNeill,Violet Yuen,Raymond J Andersen,Stephen G Withers,Gary D Brayer

Nature chemical biology（2015）

引用 97|浏览8

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摘要

Montbretin A is a potent inhibitor of amylase, an enzyme critical in starch digestion and thus of relevance for diabetes and obesity. Structural and biochemical analyses now show that a minimal core of the glycoside π-stacks on itself to fit into the active site.

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关键词

Enzymes, Dietary carbohydrates, Structure-based drug design, X-ray crystallography

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