mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress

Sora Shin,Obin Kwon,Jee In Kang,Somin Kwon,Sora Oh,Jiwon Choi,Chul Hoon Kim,Dong Goo Kim

Nature neuroscience（2015）

引用 111|浏览7

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摘要

The authors showed that mGluR5 can upregulate the expression of ΔFosB, a resilience molecule, in the nucleus accumbens. In stress-induced animal models of depression, mGluR5-induced upregulation of ΔFosB in the nucleus accumbens enhances resilience to stress.

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关键词

Depression,Stress and resilience,Striatum,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics

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