Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking

Shuyong Zhu,Chengjiang Zhao,Yingying Wu,Qiaoqiao Yang,Aiyun Shao,Tiepeng Wang,Jianfu Wu,Yanqing Yin,Yandong Li,Jincan Hou,Xinhua Zhang,Guomin Zhou,Xiaosong Gu,Xiaomin Wang,Xosé R Bustelo,Jiawei Zhou

Nature neuroscience（2015）

引用 36|浏览14

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摘要

The molecular mechanisms underlying the regulation of dopamine transporter activity in the brain remain poorly understood. The authors show that glial cell line–derived neurotrophic factor, its receptor Ret and the Rho family GEF protein Vav2 are required for modulating dopamine transporter cell surface expression and transporter activity in the nucleus accumbens.

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关键词

Membrane trafficking,Molecular neuroscience,Striatum,Transporters in the nervous system,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics

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