Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
Nature neuroscience(2015)
摘要
Chronic social stress has adverse behavioral consequences and can result in the development of depression in humans. Using a rodent social stress model, we report increased synaptic connectivity between the thalamus and striatum in susceptible mice that controls behavioral coping mechanisms relevant to depression.
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关键词
Depression,Neural circuits,Stress and resilience,Striatum,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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