Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

Lanfeng Wang,Yu Zhou,Liang Xu,Rui Xiao,Xingyu Lu,Liang Chen,Jenny Chong,Hairi Li,Chuan He,Xiang-Dong Fu,Dong Wang

Nature（2015）

引用 164|浏览16

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摘要

Structural and biochemical studies of RNA polymerase II (Pol II) assembled on DNA containing 5-carboxycytosine reveals that Pol II can sense the oxidized methylation state of DNA and transiently slows down during transcription.

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关键词

Transcription, DNA metabolism, X-ray crystallography, DNA methylation

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