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Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

Justin E Wilson,Alex S Petrucelli,Liang Chen, A Alicia Koblansky,Agnieszka D Truax,Yoshitaka Oyama,Arlin B Rogers,W June Brickey,Yuli Wang,Monika Schneider,Marcus Mühlbauer,Wei-Chun Chou,Brianne R Barker,Christian Jobin,Nancy L Allbritton,Dale A Ramsden,Beckley K Davis,Jenny P Y Ting

NATURE MEDICINE（2015）

引用 219|浏览13
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摘要
IM2 suppresses colon tumorigenesis, independently of the inflammasome and IL-1β, by interacting with DNA-PK and inhibiting Akt activation.
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nature medicine, science
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