5-Formylcytosine can be a stable DNA modification in mammals

Martin Bachman,Santiago Uribe-Lewis, Xiaoping Yang,Heather E Burgess,Mario Iurlaro,Wolf Reik,Adele Murrell,Shankar Balasubramanian

Nature Chemical Biology（2015）

引用 210|浏览27

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摘要

5-Formylcytosine (5fC), produced by TET-mediated oxidation of 5-methylcytosine, is considered an intermediate in active DNA demethylation. Labeling studies and LC/MS analysis across mouse developmental stages reveals that 5fC modifications are more persistent in the genome and may have other functional roles.

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关键词

DNA,DNA metabolism,Nucleic acids,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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