NCI-H295R cell line as in vitro model of hyperaldosteronism lacks functional KCNJ5 (GIRK4; Kir3.4) channels.

Marie-Cécile Kienitz,Evanthia Mergia,Lutz Pott

Molecular and Cellular Endocrinology（2015）

引用 6|浏览11

暂无评分

摘要

•We investigated basal and G protein-activated GIRK4 currents in H295R cells.•GIRK4 protein can be detected in Western blots of H295R homogenates.•GTP-γ-S did not activate basal GIRK4 currents in native H295R cells.•Basal and agonist-activated GIRK4 currents were recorded in KCNJ5-infected cells.•GIRK4 protein in H295R cells does not form functional Gβγ-activated channels.

查看译文

关键词

GIRK4,KCNJ5,Primary aldosteronism,Adrenocortical cell line,Electrophysiology

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要