Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.

Lun Zhou,Jielin Liu,Patrick Olson,Ke Zhang,Joshua Wynne,Linglin Xie

Journal of Molecular and Cellular Cardiology（2015）

引用 42|浏览3

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摘要

•Osr1 and Tbx5 interact for cardiac septation.•Regulation of Osr1 by Tbx5 in posterior SHF is time-sensitive.•Tbx5 and Osr1 interact to regulate the atrial progenitor cell cycle progression.•Pten knockdown rescued AVSDs caused by Osr1 and Tbx5 compound haploinsufficiency.•Integrity of the Hh signaling was dependent on Osr1 level and is time-sensitive.

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关键词

AVSDs,ASDs,SV,DMP,PAS,SHF,HOS,Osr1

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