The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

A Carolin Seefeldt,Fabian Nguyen,Stéphanie Antunes,Natacha Pérébaskine,Michael Graf,Stefan Arenz,K Kishore Inampudi,Céline Douat,Gilles Guichard,Daniel N Wilson,C Axel Innis

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2015）

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摘要

Structural and biochemical studies reveal how the antimicrobial peptide Onc112 binds to bacterial ribosomes and show that Onc112 blocks and destabilizes the translation-initiation complex.

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nature structural and molecular biology, science

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