Bile acid binding resin improves hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver.

Hirotsune Tagawa,Junichiro Irie,Arata Itoh,Yukie Kusumoto,Mari Kato,Nana Kobayashi,Kumiko Tanaka,Rieko Morinaga,Masataka Fujita,Yuya Nakajima,Kohkichi Morimoto,Taichi Sugizaki,Yoshinaga Kawano,Satoru Yamada,Toshihide Kawai,Mitsuhiro Watanabe,Hiroshi Itoh

Diabetes Research and Clinical Practice（2015）

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摘要

•Bile acid binding resin improved hepatic insulin sensitivity by reducing cholesterol but not triglyceride in the liver.•Fatty liver shionogi mice developed hepatic fat accumulation without dietary intervention.•Bile acid binding resin improved glycemic controls in the patients with type 2 diabetes without reducing fat mass.

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关键词

Bile acid binding resin,Hepatic insulin resistance,Non-alcoholic fatty liver disease

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