Therapeutic ultrasound: Increased HDL-Cholesterol following infusions of acoustic microspheres and apolipoprotein A-I plasmids.

Jason W Castle,Kevin P Kent,Ying Fan,Kirk D Wallace,Cynthia E L Davis,Jeannette C Roberts,Michael E Marino,Kai E Thomenius, Hae W Lim,Eric Coles,Michael H Davidson,Steven B Feinstein,Anthony DeMaria

Atherosclerosis（2015）

引用 13|浏览13

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摘要

•Sonoporation, via acoustic microspheres with ApoA-I pDNA, resulted in increased HDL-C.•HDL-C therapy using localized, acoustic delivery is devoid of viral-mediated vectors.•A novel therapeutic, gene delivery system was developed for hypo-alphalipoproteinemia.

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关键词

ApoA-I,Optison™,Acoustic microspheres,Ultrasound,Drug delivery,HDL-C,Hypo-alphalipoproteinemia

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