Perinatal methylmercury exposure perturbs the expression of Plp1 and Cnp splice variants in cerebellum of rat pups.

•Plp1 and Cnp genes are highly expressed in oligodendrocyte cells.•We identified and characterized new Plp1 and Cnp splice variants in rat brain.•We designed primers to measure total/individual splice variants levels of these genes.•Perinatal MeHg exposure reduced Plp1 and Cnp transcript levels in pup's cerebellum.•Our results confirm that MeHg impacts oligodendrocytes in the developing brain.