The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse model of motor neuron disease.

Neuroscience(2015)

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摘要
•Mild-TBI did not alter the lifespan of G93A mice or the age of onset.•TBI resulted in impaired rotarod performance, grip strength was reduced in TG mice.•Electromyography indicates that TBI causes peripheral effects that are increased in G93A mice.•Inflammation was detected in the brain and spinal cord by 72h in WT and G93A mice.•Isoprostanes increase in WT spinal cord post TBI to levels comparable to G93A mice.
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关键词
ALS,CST,EMG,GFAP,MND,RT,TBI
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