Monitoring of multiple solid-state transformations at tablet surfaces using multi-series near-infrared hyperspectral imaging and multivariate curve resolution.

•Monitoring solid-state transformations at tablet surfaces in different temperatures.•Blends of piroxicam monohydrate, PVP and lactose forms monohydrate or anhydrate.•Multi-series near-infrared hyperspectral imaging and multivariate curve resolution.•Resolution of the profile of each compound in the tablets along the experiment.•Dehydration of piroxicam and lactose monohydrates was mapped separately.