A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: A single center, randomized, blinded trial.

•The incidence of postcraniotomy headache (PCH) has been reported between 55 and 60%.•The effect of preoperatively administered NSAID on the severity of PCH was tested.•Preoperative diclofenac decreases severity of PCH in the early postoperative period.•Post-operative analgesic requirements could also be decreased.