Quantitative and qualitative effect of gH625 on the nanoliposome-mediated delivery of mitoxantrone anticancer drug to HeLa cells.

Perillo Emiliana,Allard-Vannier Emilie,Falanga Annarita,Stiuso Paola,Vitiello Maria Teresa,Galdiero Massimiliano,Galdiero Stefania,Chourpa Igor

International Journal of Pharmaceutics（2015）

引用 32|浏览9

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摘要

•Mitoxantrone (MTX) drug was delivered to HeLa cells by gH625 decorated liposomes.•An enhanced quantity of MTX was delivered and lead to an increased cytotoxicity.•The action mechanism involves the formation of an oxidative MTX metabolite.

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关键词

Nanoliposomes,Polyethylene glycol (PEG),Cell penetrating peptide (CPP),gH625,Anticancer drug mitoxantrone (MTX)

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