Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: A Potential Diagnostic Pitfall

Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+LBCL) is a rare variant of LBCL with an abnormal immunophenotype, which is easily misdiagnosed as carcinoma or plasma cell neoplasm. Here, we present two cases of ALK+LBCL in the lymph node; describe their clinical, pathological, and immunophenotype features; and compare them with those of the reported cases.