Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells.

Hui Kenrie P Y,Kuok Denise I T,Kang Sara S R,Li Hung-Sing,Ng Mandy M T,Bui Christine H T,Peiris J S Malik,Chan Renee W Y,Chan Michael C W

Antiviral Research（2015）

引用 14|浏览58

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摘要

•Simvastatin inhibited virus replication and cytokine production by H5N1 virus.•Zometa and FPT inhibitor III inhibited both H5N1 and H1N1 replication.•FPT inhibitor III is a strong immuno-regulator during H5N1 infection.•Protein farnesylation plays a role in cytokine induction by H5N1 virus.

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关键词

Influenza A virus,Sterol biosynthesis,Farnesyl transferase inhibitor,Statin,Zometa,Cytokine

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