Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673.

Alexandra-Zoe Andrei,Anita Hall,Alyssa L Smith,Claire Bascuñana,Abba Malina,Ashton Connor,Gulbeyaz Altinel-Omeroglu,Sidong Huang,Jerry Pelletier,David Huntsman,Steven Gallinger,Atilla Omeroglu,Peter Metrakos,George Zogopoulos

Cancer Letters（2015）

引用 26|浏览11

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摘要

•BRCA2-associated PDAC is sensitive to agents exploiting DNA repair defects.•BRCA2-deficient PDAC cells are sensitive to cisplatin and BMN 673.•BMN 673 inhibits tumor growth by 61% in a BRCA2 PDAC xenograft model.

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关键词

Pancreatic ductal adenocarcinoma,BRCA2,DNA repair,BMN 673,Personalized medicine

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