A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity.

•We propose a model of seizure-like events in temporal cortex slices from young mice.•In the model local NMDA stimulations induce multiple seizure-like events.•Electrophysiological, Ca2+ imaging and optogenetics are combined in the model.•Seizures generation and propagation are separately studied.•The role of specific cell population on these events can be accurately analyzed.