A functional perspective of nitazoxanide as a potential anticancer drug.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2014）

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摘要

•Combination anti-cancer therapies are associated with increased toxicity and cross-resistance.•Some antiparasitic compounds may have anti-cancer potential.•Nitazoxanide interferes with metabolic and pro-death signaling.•Preclinical studies are needed to confirm anticancer ability of nitazoxanide.

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关键词

Autophagy,Protein disulfide isomerase,Microenvironment,Nitazoxanide,c-Myc,Glutathione S-transferase,Interleukin 6

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