Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats.

Shun-Mei Lu,Bo Gui,Hong-Quan Dong,Xiang Zhang,Su-Su Zhang,Liu-Qing Hu,Hai-Ling Liu, Jie Sun,Yian-Ning Qian

Brain Research Bulletin（2015）

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摘要

•Lithium and TLR4 siRNA treatment decrease TNF-α and TLR4 mRNA expression.•Lithium treatment alleviates cognitive impairments after splenectomy in aged rats.•Prophylactic lithium alleviates inflammation and CD11b+ area after the surgery.•Splenectomy merely increases hippocampal TLR2 and TLR4 mRNA levels in aged rats.•Prophylactic lithium inhibits hippocampal TLR4/NF-κB expression induced by surgery.

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CNS,CSF,DMEM,ELISA,FBS,GAPDH,GSK-3β,HRP,IL-1β,InsP3 R1,LiCl,LPS,LTP,MWM,NCS-1,OFT,PI3K,POCD,TLR4,TNF-α

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