Differential interaction of hGDH1 and hGDH2 with manganese: Implications for metabolism and toxicity.

Christina Dimovasili,Michael Aschner,Andreas Plaitakis,Ioannis Zaganas

Neurochemistry International（2015）

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摘要

•Effect of Mn on human glutamate dehydrogenases (hGDH1 and hGDH2) was studied.•Mn exerted a significant inhibitory effect on both hGDH1 and hGDH2.•hGDH2 was more sensitive than hGDH1 to Mn, especially under low ADP levels.•Mn-induced inhibition was more co-operative for hGDH2 than for hGDH1.•These findings might be of pathophysiological relevance for Mn neurotoxicity.

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关键词

Manganese,Glutamate dehydrogenase,hGDH1,hGDH2,ADP,Mitochondria

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