N-acetyl-aspartyl-glutamate and inhibition of glutamate carboxypeptidases protects against soman-induced neuropathology.

Huifu Guo,Jiong Liu,Kerry Van Shura,HuaZhen Chen,Michael N Flora,Todd M Myers,John H McDonough,Joseph T McCabe

NeuroToxicology（2015）

引用 11|浏览3

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摘要

•N-acetyl-aspartyl-glutamate (NAAG) is the most abundant neuropeptide in the CNS.•We model soman neuropathology in rats.•Animals treated with compounds to facilitate NAAG function reduced neuropathology.•NAAG compounds may be therapeutically beneficial after nerve agent exposure.

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关键词

2-Phosphonomethyl pentanedioic acid (2-PMPA),Brain injury,High performance liquid chromatography,Effect size

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