Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin.

M J Eimerbrink, J D White,R J Pendry,S L Hodges,L N Sadler,J D Wiles,M K Weintraub,M J Chumley,G W Boehm

Behavioural Brain Research（2015）

引用 6|浏览2

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摘要

•MRK-016 rescued memory acquisition following peripheral LPS administration.•MRK-016 rescued memory consolidation following peripheral LPS administration.•Behavioral differences occurred independently of BDNF mRNA expression.•Neither LPS nor MRK-016 administration altered IGF-1 mRNA expression.

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关键词

Hippocampus,Inflammation,Lipopolysaccharide,LPS,BDNF,IGF-1

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