A comparison of 454 sequencing and clonal sequencing for the characterization of hepatitis C virus NS3 variants.

Cynthia K Y Ho,Matthijs R A Welkers,Xiomara V Thomas,James C Sullivan,Tara L Kieffer,Henk W Reesink,Sjoerd P H Rebers,Menno D de Jong,Janke Schinkel,Richard Molenkamp

Journal of Virological Methods（2015）

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摘要

•Characterization of HCV NS3 variants by 454 and clonal sequencing was compared.•No significant differences were found in Shannon entropy/average pairwise distance.•Consensus sequences and phylogenetic tree topology were similar.•454 sequencing was superior in characterizing low frequency variants.•For intra-host diversity and population structure both methods were comparable.

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关键词

APD,HCV,IQR,NGS,NJ,NSE,SRA,SD,RAVs,TVR,V

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