Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats.

Ramin Raoof,Saeed Esmaeili-Mahani,Mehdi Abbasnejad,Maryam Raoof,Vahid Sheibani,Razieh Kooshki,Ladan Amirkhosravi,Foroozan Rafie

Neuropeptides（2015）

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摘要

•Intradental application of capsaicin (100 µg/rat) significantly affected nociceptive behaviors.•Capsaicin-induced pulpal pain impairs spatial learning and memory ability of male rats in the Morris water maze.•The levels of orexin 1 receptor mRNA and protein in the hippocampus of capsaicin-treated rats were significantly decreased.

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关键词

Tooth inflammatory pulpal pain,Orexin 1 receptor,Learning and memory,Capsaicin,Gene expression

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