Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.

Naoki Kimata,Philip J Reeves,Steven O Smith

Journal of Magnetic Resonance（2015）

引用 11|浏览12

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摘要

•A model is proposed for the conformational triggers that activate rhodopsin.•One trigger involves a steric contact between the retinal and Phe261.•A second trigger involves a shift in the position of Tyr191.•NMR measurements highlight structural changes not seen in crystal structures.

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关键词

Solid-state NMR spectroscopy,G protein-coupled receptor,Magic angle spinning

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