The different expression profiles of microRNAs in elderly and young human dental pulp and the role of miR-433 in human dental pulp cells.

•Conduct expression profiles of miRNAs in HDPCs of young and elderly people.•MiR-433 was most up-regulated in the aging group and direct target GRB2.•MiR-433 control the RAS–MAPK signaling pathway by negatively regulating GRB2.•MiR-433 can affect HDPCs biological behavior and function during senescence.•MiR-433 may be the potential target in promoting repair and regeneration in HDPCs.