Repeated low-dose 17β-estradiol treatment prevents activation of apoptotic signaling both in the synaptosomal and cellular fraction in rat prefrontal cortex following cerebral ischemia.

Miloš Stanojlović,Jelena Zlatković,Ivana Guševac,Ivana Grković,Nataša Mitrović,Marina Zarić,Anica Horvat,Dunja Drakulić

Neurochemistry International（2015）

引用 12|浏览8

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摘要

•Neuronal cell loss has been documented in rats following cerebral ischemia.•Seven-day E therapy decreased DNA fragmentation and occurrence of degenerating neurons.•E prevents activation of 2VO-induced synaptosomal and cellular proapoptotic cascade.•Modulation of proapoptotic signaling involves cooperative Erk and Akt activation.

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关键词

Permanent bilateral common carotid arteries occlusion (two-vessel occlusion, 2VO),Pro-apoptotic signaling,17β-Estradiol (E),Prefrontal cortex

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