Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

Etienne Meunier,Pierre Wallet, Roland F Dreier, Stéphanie Costanzo,Leonie Anton,Sebastian Rühl,Sébastien Dussurgey,Mathias S Dick,Anne Kistner,Mélanie Rigard,Daniel Degrandi,Klaus Pfeffer,Masahiro Yamamoto,Thomas Henry,Petr Broz

NATURE IMMUNOLOGY（2015）

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摘要

How host cells induce the release of DNA from cytosolic bacteria is unclear. Broz and colleagues show that the guanylate-binding proteins GBP2 and GBP5 trigger bacteriolysis in infected host cells and thereby allow recognition by the sensor AIM2.

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nature immunology, science

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