Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, pp. 1126-1138, 2015.

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Keywords:
single muscle fiberdiaphragm weaknessmechanical ventilationweaning failure

Abstract:

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood. Objectives: We hypothesized that diaphra...More

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