Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

    American journal of respiratory and critical care medicine, Volume 191, Issue 10, 2015, Pages 1126-1138.

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    Keywords:
    diaphragm weaknessmechanical ventilationsingle muscle fiberweaning failure

    Abstract:

    The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood.We hypothesized that diaphragm muscle fibers of mech...More

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