Inhibition of the histone lysine methyltransferase EZH2 for the treatment of cancer.
CURRENT TOPICS IN MEDICINAL CHEMISTRY(2015)
摘要
In recent years, there has been an increased effort in the development of therapies which target an epigenetic mode of action. Among thes e efforts include progress in the development of inhibitors of EZH2 (Enhancer of Zeste Homolog 2), a key epigenetic target with strong disease implications to cancer. Over the last 3+ years, multiple reports describing small molecule inhibitors of EZH2 have been described, including those for chemical probes and drug candidates which have entered the clinic as first-in-class agents. Recent progress in this emerging area is presented in this review.
更多查看译文
关键词
Chromatin,epigenetics,histone methyltransferases,nucleosome,post-translational modification
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要