L-DOPA decarboxylase mRNA levels provide high diagnostic accuracy and discrimination between clear cell and non-clear cell subtypes in renal cell carcinoma.

Emmanuel I Papadopoulos,Constantina Petraki,Alkiviadis Gregorakis,Eleni Chra,Emmanuel G Fragoulis,Andreas Scorilas

Clinical Biochemistry（2015）

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摘要

•DDC expression is dramatically downregulated in renal cell carcinoma.•DDC mRNA levels exhibit high diagnostic accuracy for RCC tissue specimens.•Clear cell and non-clear cell RCC subtypes can be discriminated by DDC mRNA levels.•Tumor grade of RCC is inversely correlated with DDC mRNA expression.

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关键词

L-DOPA decarboxylase,Renal cell carcinoma,Molecular marker,Real-time PCR

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