Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.

The microsomal epoxide hydrolase 1 (EPHX1) Tyr113His and His139Arg polymorphisms have been reported to be associated with esophageal cancer (EC) risk, yet the results of these previous results have been inconsistent or controversial. The objective of this study was to explore whether the EPHX1 Tyr113His and His139Arg polymorphisms confer risk to EC. The relevant studies were identified through a search of PubMed, Excerpta Medica Database (Embase), Elsevier Science Direct, and Chinese Biomedical Literature Database until May 2013. The association between the EPHX1 Tyr113His and His139Arg polymorphisms and EC risk was pooled by odds ratios (ORs) together with their 95% confidence intervals (95%CIs). A total of eight case-control studies with 1163 EC patients and 1868 controls (seven studies for both Tyr113His and His139Arg polymorphisms, one study only for Tyr113His polymorphism) were eventually identified. We found no association between EPHX1 Tyr113His and His139Arg polymorphisms and EC risk in overall population (For Tyr113His: His vs. Tyr: OR=1.05, 95%CI=0.95-1.15, P=0.379; His/His vs. Tyr/Tyr: OR=1.04, 95%CI=0.88-1.22, P=0.208; His/Tyr vs. Tyr/Tyr: OR=0.96, 95%CI=0.80-1.15, P=0.577; His/His vs. His/Tyr+Tyr/Tyr: OR=1.10, 95%CI=0.96-1.26, P=0.164; His/His+His/Tyr vs. Tyr/Tyr: OR=1.01, 95%CI=0.90-1.12, P=0.543. For His139Arg: Arg vs. His: OR=1.04, 95%CI=0.94-1.14, P=0.465; Arg/Arg vs. His/His: OR=1.06, 95%CI=0.91-1.24, P=0.470; Arg/His vs. His/His: OR=1.03, 95%CI=0.91-1.16, P=0.673; Arg/Arg vs. Arg/His+His/His: OR=1.04, 95%CI=0.85-1.27, P=0.708; Arg/Arg+Arg/His vs. His/His: OR=1.02, 95%CI=0.93-1.13, P=0.617). In subgroup analysis based on ethnicity, significant association has been found in neither EPHX1 Tyr113His nor His139Arg polymorphism. The current meta-analysis suggests no evidence of association between the EPHX1 polymorphism and EC risk.